Health Care

The Hair Loss Anatomy and Genetics

The genetic hair loss is scientifically known as the Androgenic alopecia or AGA usually characterized by the progressive thinning of the scalp’s hair and recession come in a continuum affects the all over the scalp areas, except the back and sides of the head. The back sides of the scalp contain the DHT-resistant hair roots that are resistant to the effect of the miniaturization or hair loss. The significant association of genetic hair loss has been identified with diverse regions of the Androgen receptor gene, located on the X-chromosome. The hair transplant in Delhi allows a patient to get the best inaugural discount along with the best facilities and amenities adhered to the cutting-edge technology, the standard measure for the safety and hygienic concern as well as the topmost quality measurement concern.

The goal of the hair transplant surgery is to cover the over all areas of the scalp by extracting the graft from the safe donor part of the scalp. The scalp may be divided into 4 categories, viz. frontal, mid-scalp, vertex, and temporal areas. All these areas need to be covered with the live hair follicles obtained via the extraction job followed by the microscopic dissection.

The Physiology of Hair Loss:

The process of miniaturization is an initial sign of hair loss that is characterized by the severe thinning, destruction of hair follicles, as well as the severe hair fall condition. It is very important to understand the physiology of hair loss that is explained on the basis of the miniaturization process. The miniaturized hair is characterized by the shortening of the Anagen phase as well as the increasing the Telogen stage of the hair growth cycle that disrupt the hair growth cycle. Miniaturization results in the conversion of large hair into smaller ones, barely noticed and depigmentation starts for the vellus hairs. The most identified reason for the miniaturization occurs due to a decrease of dermal papilla volume and significantly reduces the hair follicle growth. The hair follicle in the miniaturization process gets affected; subsequently, decrease the number of cells per papilla.

The Genetics of Hair loss:

The balding scalp contains the highest concentration for the 5-alpha-reductase, DHT, and the DHT androgen receptor. The baldness appears as an effect of the DHT formation, a form of the Testosterone hormone. The DHT or Di-hydro Testosterone produces due to the catalytic effect of the procedure that involves 5-alpha catalysis. Although, testosterone is the only responsible factor for causing genetic hair loss and presents the case of male pattern hair loss and the female pattern hair loss respectively. Testosterone is a major circulating androgen that goes through the catalytic process with the enzyme, 5-alpha-reductase. The recent scientific data revealed this fact that the Androgenic alopecia is a polygenic trait. The DHT-action is processed through the intracellular nuclear Androgen receptors.


As a matter of the fact, the sign of miniaturization is most significant with the process of shortening the Anagen, or growth phase of the hair cycle as well as the increase in the Telogen or resting stage of the hair follicle growth cycle. The only treatment to address the Androgenic alopecia permanently is the hair transplant procedure.